2024, Vol. 12, Issue 3, Part B

author(s)
Manoharan Karuppiah Pillai and Qhawe Bonginkhosi Mangwe

abstract
Vangueria infausta has been used in the traditional medicine. In this research, we focused to analyze the phytochemical constituents, to evaluate the antioxidant activity and to determine the IC₅₀ values of various solvent extracts obtained from the leaves and stem-bark of V. infausta. Maceration technique together with hot solvent extraction approach was used for the obtainment of various solvent extracts. Phytochemical analysis, DPPH radical scavenging potential and IC₅₀ values were performed as per established procedures. Several classes of phytochemicals were identified in these extracts. The radical scavenging potential of these extracts and positive control were found to be in the ranges of 2.115±0.024 - 75.668±0.001% and 53.076±0.023^-86.083±0.045% at 200-3000 µg/mL. The methanol extracts from the leaves and stem-bark and positive control exhibited IC₅₀ values of 732.170 and 1235.862 µg/mL and <200 µg/mL, respectively. V. infausta possessed various classes of phytochemicals and showed a weak to moderate DPPH radical scavenging potential.